Skip to main content

Table 2 Naloxone (4 mg/ml) administered intravenously

From: Effect of a high-dose target-controlled naloxone infusion on pain and hyperalgesia in patients following groin hernia repair: study protocol for a randomized controlled trial

 

Time (min)

Dose (mg/kg)

Dose/70 kg (mg)

Volume/70 kg (ml)

ml/min/70 kg

Bolus 1

0–1

0.02

1.40

0.35

0.35

Infusion 1

1–25

0.23

16.10

4.03

0.17

Bolus 2

25–26

0.06

4.20

1.05

1.05

Infusion 2

26–50

0.69

48.30

12.08

0.50

Bolus 3

50–51

0.18

12.60

3.15

3.15

Infusion 3

51–75

2.07

144.90

36.23

1.51

TOTAL

 

3.25

227.50

56.88

 
  1. Timeline, dose/kg, dose/70 kg, volume/70 kg and infusion rates/min/70 kg for the 3 step target-controlledinfusion. The total naloxone-dose administered is 227.5 mg per 70 kg BW. The total naloxone volume is 56.9 ml per 70 kg BW. BW: body weight (kg)