Table 2 Predefined group and subgroup analyses according to treatment allocation
From: Treatment of Brain AVMs (TOBAS): study protocol for a pragmatic randomized controlled trial
Stratified randomized allocation | Groups: Intervention group versus Observation group |
|---|---|
| Â | Surgery subgroup versus Observation subgroup |
| Â | Radiosurgery subgroup versus Observation subgroup |
| Â | Embolization subgroup versus Observation subgroup |
Randomization on pre-embolization | Groups: Embolization versus No embolization |
|  | Embo + surgery subgroup versus Surgery alone subgroup |
|  | Embo + radiosurgery subgroup versus Radiosurgery subgroup |
Registry | Â |
| Â | Conservative management |
| Â | Surgical treatment (alone) |
| Â | Surgical treatment (with embolization) |
| Â | Radiotherapy (alone) |
| Â | Radiotherapy (with embolization) |
| Â | Embolization (alone) |
|  | Embolization + surgery |
|  | Embolization + radiotherapy |
According to presentation | Unruptured AVM patients |
| Â | Ruptured AVM patients |
According to SM grading | Low-grade AVM patients |
| Â | High-grade AVM patients |