Table 1 Baseline clinical characteristics, expressed as percentages or as medians and interquartile ranges
Variable | All patients | Group A | Group B | P | |
|---|---|---|---|---|---|
(Patients who met ISCHEMIA exclusion criteria) | (Patients who did not meet ISCHEMIA exclusion criteria) | (A vs. B) | |||
n = 3102 | n = 1900 | n = 1202 | |||
Median age, years | 64 (57–71) | 64 (57–72) | 64 (57–70) | 0.11 | |
Men | 2187 (70.5) | 1354 (71.3) | 833 (69.3) | 0.26 | |
Previous myocardial infarction | 1786 (57.6) | 1335 (70.3) | 451 (37.5) | <0.001 | |
Previous percutaneous coronary intervention | 1451 (46.9) | 1166 (61.4) | 285 (23.7) | <0.001 | |
Previous coronary artery bypass graft | 407 (13.1) | 253 (13.3) | 154 (12.8) | 0.7 | |
Diabetes | 1118 (36.1) | 785 (41.3) | 333 (27.8) | <0.001 | |
Diabetes treatment | Diet only | 238 (7.7) | 1176 (9.3) | 62 (5.2) | <0.001 |
Insulin | 433 (14.0) | 284 (14.9) | 149 (12.4) | ||
Oral drugs | 447 (14.4) | 325 (17.1) | 670 (55.7) | ||
Hypertension | 2217 (71.5) | 1301 (68.5) | 916 (76.2) | <0.001 | |
Hypercholesterolemia | 1752 (56.5) | 1082 (57) | 670 (55.7) | 0.53 | |
Current smoker | 1140 (36.9) | 719 (37.8) | 421 (35) | 0.09 | |
Past smoker | 331 (10.7) | 187 (9.8) | 144 (12) | 0.09 | |
Obesity | 1035 (33.4) | 626 (33) | 409 (34) | 0.56 | |
Family history of premature myocardial infarction (<55 years) | 256 (9.3) | 155 (8.3) | 131 (10.9) | 0.01 | |
Systolic blood pressure (mmHg) | 130 (120–140) | 130 (120–140) | 130 (120–140) | <0.001 | |
Diastolic blood pressure (mmHg) | 80 (70–85) | 80 (70–85) | 80 (70–85) | 0.03 | |
Heart rate (min−1) | 70 (63–76) | 70 (63–77) | 70 (64–76) | 0.32 | |
Heart failure | 568 (18.3) | 496 (26.1) | 72 (6) | <0.001 | |
Ejection fraction (%) | 48 (40–55) | 45 (35–50) | 50 (46–55) | <0.001 | |
Mitral valve regurgitation, severe | 75 (2.5) | 75 (4.1) | 0 | <0.001 | |
Mitral valve stenosis, severe | 4 (0.1) | 4 (0.2) | 0 | ||
Aortic stenosis, severe | 24 (0.8) | 24 (1.3) | 0 | ||
Aortic regurgitation, severe | 7 (0.2) | 7 (0.4) | 0 | <0.001 | |
Aortic valve insufficiency, combined | 5 (0.2) | 5 (0.3) | 0 | ||
Bicuspid aortic valve | 6 (0.2) | 6 (0.3) | 0 | ||
Tricuspid regurgitation, severe | 26 (0.9) | 26 (1.4) | 0 | <0.001 | |