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Table 1 Secondary outcomes and the appropriate measuring method

From: Effect of a patient-centered drug review on polypharmacy in primary care patients: study protocol for a cluster-randomized controlled trial

Secondary outcomes Measuring method
1. Change in the number of drugs immediately after the encounter and 6 months later Medication list at baseline and after 6 months
2. Reason for a change, categorized in the 4 options of the algorithm, number of drugs in each category 12 months after applying the tool Medication list of the changed medications after the intervention, with the reason for a change
3. Discrepancy in the decision to quit, change or continue the drug between PCP and patient Medication list after intervention with any suggestion from the PCP for a change; medication list after the intervention and after shared-decision-making
4. Number of drugs for which the patient is suggesting a change Medication lists at baseline, after 6 and 12 months
5. Number of drugs the patient is taking not known to the PCP Medication lists at baseline, after 6 and 12 months
6. Time consumption of the intervention Measurement of the time through the practice nurse and the PCP
7. Disease-specific variables to evaluate the course of the disease(s) for which the patient is being treated Symptom scores and measurements of biometric analysis (e.g. blood pressure monitoring, serum glucose) and VAS scales (e.g. pain). Event rates (hospitalization, death) and unexpected adverse event rates
8. Number of drugs readopted due to an unfavorable course of the disease(s) (readoption rate) Medication lists at baseline, after 6 and 12 months
9. Quality of life (QoL) Patient rating on a 5-point Likert scale
EQ-5D-3 L at baseline, after 6 and 12 months
10. Barriers perceived by patients and PCPs against the approach/algorithm Phone interview with the patients 13 months after intervention
11. Number of drugs which have been started Medication lists at baseline, after 6 and 12 months
  1. EQ-5D-3 L EuroQol health status measure, PCP primary care practitioner, VAS visual analogue scale