Apixaban versus Antiplatelet drugs or no antithrombotic drugs after anticoagulation-associated intraCerebral HaEmorrhage in patients with Atrial Fibrillation (APACHE-AF): study protocol for a randomised controlled trial

Table 2 Possible treatments in both trial arms

Arm 1: apixaban	Arm 2: avoid anticoagulation
Apixaban 5 mg twice daily	No antithrombotic treatment
Apixaban 2.5 mg twice daily^a	Acetylsalicylic acid 80 mg once daily
	Carbasalate calcium 100 mg once daily
	Clopidogrel 75 mg once daily
	Acetylsalicylic acid 80 mg once daily and dipyridamole 200 mg twice daily
	Carbasalate calcium 100 mg once daily and dipyridamole 200 mg twice daily

^aReduced dose: the dose will be reduced if 2 of the 3 following criteria are met: age ≥ 80 years, body weight ≤ 60 kg or serum creatinine ≥133 μmol. If the creatinine clearance is below 30 ml per minute, the dose will also be reduced

ISSN: 1745-6215