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Table 1 Study inclusion and exclusion criteria

From: Topical clobetasol for the treatment of toxic epidermal necrolysis: study protocol for a randomized controlled trial

Inclusion criteria Exclusion criteria
Diagnosis of TEN by all of the following: Patients younger than 12 or older than 85
• Characteristic histologic findings on diagnostic biopsy Patients who have documented:
• Clinical diagnosis verified by two independent physicians • Uncontrolled infection (for example, documented bacteremia)
• Greater than 10 % eroded body surface area • Malignancy
• Negative pregnancy test in reproductive-age female patients • Known prior immunodeficiency
• Actively worsening disease (enlarging area of involvement or new erosions occurring over the previous 24 hours) • Pregnancy
• Patient body surface area > 1.0 m2 • Concurrent use of systemic corticosteroids in the burn center greater than or equal to 0.5 mg/(kg day) or prednisone or equivalent dose of systemic corticosteroid
  • Greater than 70 % eroded skin
• Hepatitis
  • SCORETEN > 3 on admission
  • Active hepatitis, or alanine transaminase or aspartate aminotransferase above four times normal limits
  • Renal insufficiency (glomerular filtration rate < 50 ml/(min*1.73 m2))