Table 3 Sample size calculations derived from an ordinal regression and based on 90 % power and alpha 0.05
Trial | Sample size | Common odds ratio | % mRS 0–2 fluoxetine | % mRS 0–2 placebo | Absolute % improvement in mRS 0-2 |
|---|---|---|---|---|---|
EFFECTS | 1500 | 1.35 | 49.5 | 42.1 | 7.4 |
AFFINITY | 1600 | 1.34 | 49.4 | 42.2 | 7.2 |
FOCUS | 3000 | 1.23 | 48.4 | 43.2 | 5.2 |
Pooled | 4500 | 1.19 | 48.0 | 43.6 | 4.4 |
Pooled | 6000 | 1.16 | 47.7 | 44.0 | 3.7 |