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Table 5 Results of the mixed model for repeated measures (MMRM) analysis of fatigue severity scale (FSS) score in the subgroups

From: Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial

Subgroup

Baseline

5 weeks

13 weeks

 

Mean (SD)

Mean (SD)

P a

LSMD (95 % CI)a

Interactionb

Mean (SD)

P a

LSMD (95 % CI)a

Interactionb

CFS (n = 63)

A

5.50 (0.94)

3.62 (1.22)

0.993

0.02 (−0.51, 0.56)

0.585c

3.43 (1.21)

0.924

−0.08 (−0.64, 0.48)

0.854c

B

5.06 (0.87)

3.75 (1.00)

0.768

−0.14 (−0.66, 0.38)

3.95 (1.05)

0.901

−0.09 (−0.64, 0.46)

C

4.74 (0.81)

4.39 (0.97)

-

-

4.44 (1.23)

-

-

ICF (n = 87)

A

4.06 (1.14)

3.21 (0.99)

0.008

−0.68 (−1.20, −0.16)

3.27 (1.15)

0.078

−0.48 (−1.01, 0.04)

B

4.50 (1.16)

3.44 (1.21)

0.188

−0.37 (−0.89, 0.14)

3.16 (1.20)

0.235

−0.35 (−0.87, 0.17)

C

4.32 (1.47)

4.51 (1.29)

-

-

4.19 (1.25)

-

-

  1. LSMD, least squares mean difference; CI, confidence interval; CFS, chronic fatigue syndrome; ICF, idiopathic chronic fatigue
  2. aP value with 95 % CI, Dunnett’s adjustment. bSubgroup treatment effect interaction. cP value