Table 2 Results of mixed model for repeated measures (MMRM) analysis of full analysis set (FAS)

FSS

A

4.67 (1.27)

3.38 (1.01)

0.023

−0.43 (−0.81, −0.05)

3.34 (1.17)

0.075

−0.36 (−0.74, 0.03)

B

4.75 (1.07)

3.58 (1.12)

0.151

−0.29 (−0.66, 0.08)

3.51 (1.19)

0.290

−0.23 (−0.62, 0.15)

C

4.48 (1.27)

4.47 (1.18)

-

-

4.28 (1.24)

-

-

SRI-short form

A

62.56 (17.95)

42.21 (14.18)

0.032

−6.01 (−11.58, −0.44)

42.28 (14.33)

0.037

−6.19 (−12.06, −0.31)

B

55.67 (14.40)

42.10 (13.66)

<0.001

−9.33 (−14.72, −3.95)

39.81 (13.55)

<0.001

−10.80 (−16.49, −5.12)

C

60.04 (18.16)

56.47 (18.03)

-

-

57.41 (20.46)

-

-

BDI

A

16.41 (8.36)

9.02 (6.92)

0.252

−1.56 (−3.94, 0.83)

9.63 (6.39)

0.231

−1.68 (−4.16, 0.81)

B

15.00 (7.67)

8.88 (7.66)

0.052

−2.34 (−4.70, 0.02)

7.89 (7.15)

0.007

−3.25 (−5.71, −0.80)

C

15.30 (7.05)

13.36 (6.39)

-

-

14.28 (8.54)

-

-

NRS

A

6.59 (1.44)

4.42 (1.98)

<0.001

−0.92 (−1.45, −0.40)

4.77 (2.22)

0.011

−0.70 (−1.26, −0.14)

B

6.55 (1.27)

4.52 (1.70)

<0.001

−0.90 (−1.42, −0.39)

4.51 (1.95)

0.002

−0.85 (−1.40, −0.29)

C

6.40 (1.40)

6.53 (1.36)

-

-

6.42 (1.69)

-

-

EQ-5D

A

0.84 (0.10)

0.91 (0.11)

0.909

−0.01 (−0.04, 0.03)

0.92 (0.11)

0.844

0.01 (−0.03, 0.04)

B

0.87 (0.09)

0.91 (0.09)

0.522

0.01 (−0.02, 0.05)

0.94 (0.08)

0.074

0.03 (0.00, 0.07)

C

0.88 (0.11)

0.88 (0.10)

-

-

0.87 (0.15)

-

-