Table 1 Schedule of events

Inclusion/exclusion

X

X

Randomisation

X

Informed consent

X

Demographics

X

Medical history

X

Concomitant medications including use of analgesics or peripheral nerve block

X

X

X^d

X

X

X

Physical examination (ROM)

X

X^d

X

X

X

Laboratory tests (virology^a, CBC^b, clinical chemistry^c)

X^a–c

X^e,b,c

Coagulation parameters (INR, PTT)

X

Treatment application

X

Intraoperative data assessment

X

Clinical outcome score assessment (KSS/KOOS)

X

X^f

X

X

X

Surgical site assessment

X^d

X

X

X

Wound healing assessment

X^d

Assessment of patient’s mobility on crutches (stairs)

X^d

Adverse events

X

X^d

X

X

X

Assessment of physiotherapy treatments after rehabilitation

X

X

X

Calculation of overall costs of TKR

X