Fig. 2

Early fungicidal activity and mortality. The left hand panel shows the crude mortality rate (per person year) calculated over the first 2 weeks of treatment according to early fungicidal activity (EFA) in the 450 patients of the 501 anti-retroviral therapy (ART)-naive patients recruited in the studies listed in Reference 2 with slope (EFA) data. Patients have been stratified by EFA, with the slowest rate of clearance being 0–0.1 log₁₀CFU/ml/day (equating to a 0 to 0.1 log drop in colony-forming units (CFU) per ml of cerebrospinal fluid (CSF) per day) and the highest rate of clearance being 0.5+ (equating to a half-log₁₀ drop or more in CFU counts/ml of CSF per day). The right hand panel shows Kaplan Meier survival curves for the 501 ART-naive patients recruited into the studies listed in Reference 2 over the first 10 weeks of treatment, stratified by EFA. The slowest rates of clearance are indicated by the solid black line (EFA 0–0.1 decline in log₁₀CFU/ml/day) and the most rapid rates of clearance are indicated by the small dotted line (EFA >0.3 decline in log₁₀CFU/ml/day)