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Table 1 Characteristics of included studies

From: Outcome reporting in randomised controlled trials and meta-analyses of appendicitis treatments in children: a systematic review

First Author Year Intervention type Study type Region of origin Sample size Age of included population
Haller Jr, [37] 1973 Surgical RCT NA 43 0 to 14 years
Bates [38] 1974 Antibiotic RCT Europe 38 0 to 9 years
Fowler [39] 1975 Antibiotic RCT Australasia 69 ‘children’
Sherman [40] 1976 Surgical RCT NA 79 13 month to 16 years
Giacomantonio [41] 1982 Antibiotic RCT NA 42 ‘pediatric age range’
Hutchinson [42] 1983 Antibiotic RCT Europe 133 16 month to 15 years
King [43] 1983 Antibiotic RCT NA 64 <18 years
Foster [14] 1987 Antibiotic RCT Europe 100 5 to 14 years
Gutierrez [44] 1987 Antibiotic RCT Europe 100 <10 years
Thomson [45] 1987 Antibiotic RCT Europe 84 4 to 13 years
McAllister [46] 1988 Antibiotic RCT Europe 401 ‘children’
Schmitt [47] 1989 Antibiotic RCT Europe 64 6 months to 15 years
Kooi [48] 1990 Antibiotic RCT Asia 100 <13 years
Meller [49] 1991 Antibiotic RCT NA 59 2 to 15 years
Pokorny [50] 1991 Antibiotic RCT NA 95 2 to 12 years
Schropp [51] 1991 Antibiotic RCT NA 97 <18 years
Kizilcan [52] 1992 Antibiotic RCT Europe 100 0 to 15 years
Tsang [53] 1992 Surgical RCT Asia 63 2 to 12 years
Uhari [54] 1992 Antibiotic RCT Europe 218 2.5 to 16.8 years
Banani [55] 1995 Antibiotic RCT Asia 246 4 to 15 years
Soderquist-Elinder [56] 1995 Antibiotic RCT Europe 544 ‘children’
Toki [57] 1995 Surgical RCT Asia 53 2 to 14 years
Lejus [27] 1996 Surgical RCT Europe 63 8 to 15 years
Ciftci [58] 1997 Antibiotic RCT Europe 200 1 to 16 years
Banani [59] 1999 Antibiotic RCT Asia 1083 4 to 15 years
Gorecki [60] 2001 Antibiotic RCT Europe 152 ‘children’
Lavonius [61] 2001 Surgical RCT Europe 43 7 to 15 years
Lintula [62] 2001 Surgical RCT Europe 61 4 to 15 years
Rice [63] 2001 Antibiotic RCT NA 26 5 to 18 years
Shalaby [64] 2001 Surgical RCT Africa 150 7 to 14 years
Lintula [65] 2002 Surgical RCT Europe 25 4 to 15 years
Little [66] 2002 Surgical RCT NA 129 1 to 16 years
Tander [67] 2003 Surgical RCT Europe 140 Mean 7.1 year
Lintula [68] 2004 Surgical RCT Europe 87 4 to 15 years
Oka [69] 2004 Surgical RCT NA 517 Mean 10.7 years
Snelling [70] 2004 Antibiotic SR NA 2284 <21 years
Andersen [19] 2005 Antibiotic SR NA NR ‘children’
Henry [71] 2005 Surgical SR NA 107 ‘children’
Schneider [72] 2005 Antibiotic RCT Europe 27 Mean 10.3 years
Aziz [73] 2006 Surgical SR NA 6,477 ‘children’
Malik [34] 2007 Surgical RCT Asia 120 3 to 18 years
Padankatti [74] 2008 Surgical RCT Asia 30 2 to 14 years
St Peter [1] 2008 Antibiotic RCT NA 100 Mean 8.6 years
Fraser [75] 2010 Antibiotic RCT NA 102 Mean 9.9 years
Pauniaho [76] 2010 Surgical RCT Europe 198 4 to 18 years
Saha [77] 2010 Surgical RCT Asia 60 <12 years
Sauerland [20] 2010 Surgical SR NA 542 ‘children’
St Peter[24] 2010 Surgical RCT NA 40 <18 years
Blakely [22] 2011 Surgical RCT NA 131 <18 years
Perez [78] 2011 Antibiotic RCT CA 100 2 to 12 years
Romero [35] 2011 Antibiotic RCT Europe 49 5 to 15 years
Schurman [23] 2011 Surgical RCT NA 40 <18 years
St Peter [26] 2011 Surgical RCT NA 360 <18 years
Esposito [79] 2012 Surgical SR NA 123,628 0 to 18 years
Markar [80] 2012 Surgical SR Europe 107,624 ‘children’
Myers [21] 2012 Surgical RCT NA 131 <18 years
St Peter [81] 2012 Surgical RCT NA 220 <18 years
Yu [82] 2013 Surgical RCT Australasia 190 8 to 14 years
Dalgic [83] 2013 Antibiotic RCT Europe 107 3 months to 17 years
Gasior [25] 2013 Surgical RCT NA 198 <18 years
Li [84] 2013 Surgical SR Asia 873 children >1 year
Nataraja [85] 2013 Surgical SR Europe 22,060 <18 years
Perez [86] 2013 Surgical RCT NA 50 2.9 to 15.7 years
  1. CA Central America, NA North America, NR not reported, RCT randomised controlled trial, SR systematic review