From: Mixed response and time-to-event endpoints for multistage single-arm phase II design
P0 | T0 | P1 | T1 | ρ a | n1 | n | Typeb | PET | α | 1-β | EN0 |
---|---|---|---|---|---|---|---|---|---|---|---|
0.05 | 3 | 0.2 | 4.5 | 0.2 | 21 | 41 | Proposed design | 0.855 | 0.055 | 0.903 | 23.900 |
Simon | 0.720 | 0.046 | 0.902 | 26.700 | |||||||
Multinomial | 0.770 | 0.072 | 0.934 | 24.600 | |||||||
0.1 | 3 | 0.3 | 5 | 0.5 | 10 | 29 | Proposed design | 0.788 | 0.052 | 0.792 | 14.028 |
Simon | 0.740 | 0.047 | 0.805 | 15.000 | |||||||
Multinomial | 0.655 | 0.039 | 0.792 | 16.900 | |||||||
0.2 | 4 | 0.4 | 8 | 0.5 | 13 | 43 | Proposed design | 0.874 | 0.053 | 0.811 | 16.780 |
Simon | 0.750 | 0.049 | 0.800 | 20.600 | |||||||
Multinomial | 0.723 | 0.049 | 0.866 | 21.300 | |||||||
0.3 | 4 | 0.5 | 8 | 0.5 | 15 | 46 | Proposed design | 0.880 | 0.042 | 0.808 | 18.720 |
Simon | 0.720 | 0.049 | 0.803 | 23.600 | |||||||
Multinomial | 0.763 | 0.062 | 0.848 | 22.100 |