Table 2 Schedule of assessment and data collection

Enrolment:

 Eligibility screening

x

 Informed consent

x

 Screening knee X-ray

x

 Screening blood test *

x

 Physical Examination

x

x

x

x

x

Interventions:

 Colchicine 0.5 mg bid

Start here

End here

 Placebo 1 tablet bid

Start here

End here

Assessments:

 Physical Examination

x

x

x

x

x

 Full blood count

x

x

 Renal function test

x

x

x

x

 Liver function test

x

x

x

x

 Uric acid

x

x

x

x

 CPK

x

x

x

x

 βHCG (for women with child bearing potential)

x

 Blood biomarkers collection

x

x

x

x

 Urine biomarkers collection

x

x

x

x

 Blood for pharmcogenomic

x

 Colchicine level

x

x

x

x

 Both knees aspiration

x

x

 Knee X-ray (both sides)

x

 MRI of signal knee ǂ (for 20 subjects only)

x

 Adverse event enquiries

x

x

x

x

 Enquiries to compliance to usual medications for knee

x

x

x

x

 Clinical data collection

x

x

 Pain score enquiries (signal knee)

x

x

x

x

 Demographic data collection

x

 WOMAC

x

x

 HAQ

x

x

 SF36v2

x

x