Muscular and functional effects of partitioning exercising muscle mass in patients with chronic obstructive pulmonary disease - a study protocol for a randomized controlled trial

Table 1 Acute and chronic phase description

Acute phase			Chronic Phase
Patients with COPD & Healthy controls			Patients with COPD
Visit 1	Visit 2 and 3*	R	Training	Visit 4	Visit 5 and 6
Visit 1	Visit 2 and 3*	A	Training	Visit 4	Visit 5 and 6
● Anthropometrics	● Muscle biopsy or 6MWT	N	High-repetitive single limb elastic band resistance training	● Anthropometrics	● Muscle biopsy (one visit)
● Voorips questionnaire		D		● Voorips questionnaire	High-repetitive single limb or two limb elastic band exercises
● CAT questionnaire †	High-repetitive single limb or two limb elastic band exercises	O		● CAT questionnaire
● CAT questionnaire †		O		● Isokinetic measurements
● Pulmonary function		M		● UULEX	● Muscle oxygenation
● Isokinetic measurements		I		● 6MWT	● Cardiorespiratory response
● UULEX †	● Muscle oxygenation	I			● Exertional symptoms
● 6MWT †	● Cardiorespiratory response	Z			● Muscle fatigability
● 25 RM testing	● Exertional symptoms	A			● Exercise stimulus
	● Muscle fatigability	T	High-repetitive two limb elastic band resistance training
	● Exercise stimulus	I
		O
		N
Baseline measurements			8 weeks training	Post assessment

*Visit order is randomized. All visits are sepearated by at least 48 h.
†Only performed by patients with COPD.
6MWT, 6-minute walk test; CAT, COPD Assessment Test; COPD, chronic obstructive pulmonary disease; RM, repetition maximum, UULEX, unsupported upper limb exercise test.

ISSN: 1745-6215