| |
Baseline
|
Three-month follow-up
|
Six-month follow-up
|
|---|
|
General characteristics
|
X
|
X
|
X
|
|
MS history
|
X
|
X
|
X
|
|
Medical history
|
X
|
X
|
X
|
|
EDSS
|
X
|
X
|
X
|
|
FIM
|
X
|
X
|
X
|
|
SEIQoL-DW*
|
X
|
X
|
X
|
|
Core-POS**
|
X
|
X
|
X
|
|
POS-S-MS**
|
X
|
X
|
X
|
|
HADS*
|
X
|
X
|
X
|
|
EQ-5D*
|
X
|
X
|
X
|
|
MSCQ
|
X
|
†
|
†
|
|
Carer characteristics /medical history
|
X
|
X
|
X
|
|
Carer HADS
|
X
|
X
|
X
|
|
Carer SF-36
|
X
|
X
|
X
|
|
Carer EQ-5D
|
X
|
X
|
X
|
|
Carer ZBI
|
X
|
X
|
X
|
- To preserve blinding, all outcome measures (except MSCQ) are assessed during examiner visits at three and six months follow-up. *Not assessed in MS patients with severe cognitive compromise or unable to communicate; **carer versions used in MS patients with severe cognitive compromise or unable to communicate; †assessed by phone interview. Core-POS, Core-Palliative care Outcome Scale; EDSS, Expanded Disability Status Scale; EQ-5D, European Quality of Life Five Dimensions; FIM, Functional Independence Measure; HADS, Hospital Anxiety and Depression Scale; MSCQ, Multiple Sclerosis foundation Costs Questionnaire; MS, multiple sclerosis; POS-S-MS, Palliative care Outcome Scale-Symptoms-Multiple Sclerosis; SF-36, Short Form 36; SEIQoL-DW, Schedule for the Evaluation of Individual Quality of Life-Direct Weighting; ZBI, Zarit Burden Interview.
