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Table 3 Cytochrome p-450 inhibitors and inducers

From: Pulsed oral sirolimus in advanced autosomal-dominant polycystic kidney disease (Vienna RAP Study): study protocol for a randomized controlled trial

CYP3A4 inhibitors:

CYP3A4 inducers

• Bromocriptine

• Carbamazepine

• Cimetidine

• Rifabutin

• Clarithromycin

• Rifampicin

• Danazol

• Phenobarbital

• Fluconazole

• Phenytoin

• Itraconazole

• St John’s Wort (Hypericum perforatum)

• Protease inhibitors

 

• Telithromycin

 
  1. To avoid potential intoxication or reduced efficacy by accidental co-administration of these substances, every participant will be handed a list of the medication above for emergency use.