Timeline for individual subject participation. Each individual will participate in the study for approximately one year. Participation will include consumption of a nutritional supplement or placebo twice daily for 42 weeks. During this time, subjects will also complete 12 weeks of resistance training followed by 26 weeks of post-training follow-up (that is, a detraining period). The particular procedures and assessments involved during each week of participation are listed. X/X denotes assessment of response to a single bout of exercise by collecting specimens before and after exercise for blood (1 hour) and muscle (72 hours). The scheduling timeline is approximate and can be extended based on the scheduling needs of the subjects and study staff.