Figure 2From: Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trialParticipant flowchart. EQ-5D, EuroQol 5D-5Â L; HADS, hospital anxiety and depression scale; ICOAP, intermittent and constant osteoarthritis pain scale; MRI, magnetic resonance imaging; MTX, methotrexate; NHS, National Health Service; NRS, numerical rating scale; OA QoL, osteoarthritis quality of life; PIS, patient information sheet; SF-12, Short Form-12; WOMAC, Western Ontario and McMaster Osteoarthritis Index. Treatment assignment and allocation concealment.Back to article page