Inclusion criteria | Exclusion criteria |
---|---|
Participant in the PICNIC project | Metastatic disease |
Informed consent obtained for being offered experimental interventions within the PICNIC project | Inflammatory bowel disease |
Informed consent obtained for questionnaires on patient-reported outcomes within the PICNIC project | Prior radiation to the pelvis |
Tumor distance of ≤10 cm from anorectal transition | Inadequate understanding of the Dutch language in speech and/or writing |
Indication for chemoradiation based on Dutch guidelines | Recent pregnancy ≤1 yr ago |
No contraindication for MRI | No indication for chemoradiation based Dutch guidelines |
World Health Organization performance status 0–2 | At least one contraindication for capecitabine administration |