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Table 1 Inclusion and exclusion criteria for the RECTAL BOOST study a

From: RandomizEd controlled trial for pre-operAtive dose-escaLation BOOST in locally advanced rectal cancer (RECTAL BOOST study): study protocol for a randomized controlled trial

Inclusion criteria Exclusion criteria
Participant in the PICNIC project Metastatic disease
Informed consent obtained for being offered experimental interventions within the PICNIC project Inflammatory bowel disease
Informed consent obtained for questionnaires on patient-reported outcomes within the PICNIC project Prior radiation to the pelvis
Tumor distance of ≤10 cm from anorectal transition Inadequate understanding of the Dutch language in speech and/or writing
Indication for chemoradiation based on Dutch guidelines Recent pregnancy ≤1 yr ago
No contraindication for MRI No indication for chemoradiation based Dutch guidelines
World Health Organization performance status 0–2 At least one contraindication for capecitabine administration
  1. aRECTAL BOOST, RandomizEd Controlled Trial for Pre-operAtive Dose-escaLation BOOST in Locally Advanced Rectal Cancer; PICNIC, ProspectIve data CollectioN Initiative on Colorectal cancer; MRI, Magnetic resonance imaging.