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Table 1 Inclusion and exclusion criteria for the RECTAL BOOST study a

From: RandomizEd controlled trial for pre-operAtive dose-escaLation BOOST in locally advanced rectal cancer (RECTAL BOOST study): study protocol for a randomized controlled trial

Inclusion criteria

Exclusion criteria

Participant in the PICNIC project

Metastatic disease

Informed consent obtained for being offered experimental interventions within the PICNIC project

Inflammatory bowel disease

Informed consent obtained for questionnaires on patient-reported outcomes within the PICNIC project

Prior radiation to the pelvis

Tumor distance of ≤10 cm from anorectal transition

Inadequate understanding of the Dutch language in speech and/or writing

Indication for chemoradiation based on Dutch guidelines

Recent pregnancy ≤1 yr ago

No contraindication for MRI

No indication for chemoradiation based Dutch guidelines

World Health Organization performance status 0–2

At least one contraindication for capecitabine administration

  1. aRECTAL BOOST, RandomizEd Controlled Trial for Pre-operAtive Dose-escaLation BOOST in Locally Advanced Rectal Cancer; PICNIC, ProspectIve data CollectioN Initiative on Colorectal cancer; MRI, Magnetic resonance imaging.