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Table 2 Reproducibility and comparability of local BeneMin magnetic resonance imaging (MRI) protocols and N-back presentation

From: The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin): study protocol for a randomised controlled trial

  Wolfson Brain Imaging Centre Cambridge MRI facility in Salford Royal NHS Foundation Trust Wellcome Trust Centre for Neuroimaging UCL Centre for Neuroimaging Sciences KCL Clinical Research Imaging Centre Edinburgh Birmingham University Imaging Centre
MRI scanner Siemens Trim Trio Philips Achieva Siemens Trim Trio GE Siemens Verio Philips Archieva
Field strength (Tesla) 3 T 3 T 3 T 3 T 3 T 3 T
Head Coil 12-channel 8-channel 12-channel 12-channel 12-channel 8-channel
MPRAGE/SPGR time 9:14 10:52 9:14 10:19 9:14 10:52
PD/T2 time 5:08 5:33 5:08 4:49 5:08 5:33
EPI time 25:02 25:04 25:00 25:04 25:02 25:08
MPRAGE/SPGR voxel size FH/IS (mm) 1 1 1 1 1 1
MPRAGE/SPGR voxel size AP (mm) 1 1 1 1 1 1
MPRAGE/SPGR voxel size RL (mm) 1 1.2 1.2 1.2 1.2 1.2
PD/T2 voxel size AP (mm) 0.9 0.9 0.9 0.9 0.9 0.9
PD/T2 voxel size RL (mm) 0.9 0.9 0.9 0.9 0.9 0.9
PD/T2 voxel size FH/IS (mm) 3 3 3 3 3 3
EPI voxel size RL (mm) 3 3 3 3.3 3.4 3
EPI voxel size AP (mm) 3 3 3 3.3 3.4 3
EPI voxel size FH/IS (mm) 4.5 4.5 4.5 4.5 4 4.5
FOV MPRAGE/SPGR FH/IS (mm) 256 256 256 260 256 256
FOV MPRAGE/SPGR AP (mm) 256 (240) 256 (240) 256 (240) 260 256 (240) 240
FOV MPRAGE/SPGR RL (mm) 192 204 192 204 176 204
FOV PD/T2 AP (mm) 240 240 240 240 240 240
FOV PD/T2 RL (mm) 240 (214) 240 (210) 240 (214) 240 240 (214) 210
FOV PD/T2 FH/IS (mm) 144 144 144 144 144 144
FOV EPI RL (mm) 192 192 192 211 220 192
FOV EPI AP (mm) 192 192 192 211 220 192
FOV EPI FH/IS (mm) 126 175.5 126 126 129 175.5
Slice plane MPRAGE/SPGR Sagittal Sagittal Sagittal Sagittal Sagittal Sagittal
Slice plane PD/T2 Transverse Transverse Transverse Transverse/axial Transverse Transverse
Slice plane EPI Transverse Transverse Transverse Transverse/axial Transverse > C-19.8 > S0.8 Transverse
EPI acquisition Interleaved Interleaved Interleaved Interleaved Interleaved Interleaved
Number of slices for MPRAGE/SPGR 176 170 160 170 160 170
Number of slices for PD/T2 48 48 48 48 48 48
Number of slices for EPI 28 39 28 28 26 39
Number of volumes for EPI 748 748 748 748 748 748
Fold-over/phase encoding direction MPRAGE/SPGR A > > P A > > P A > > P P > > A A > > P A > > P
Fold-over/phase encoding direction PD/T2 R > > L R > > L R > > L L > > R R > > L R > > L
Fold-over/phase encoding direction EPI A > > P A > > P A > > P P > > A A > > P A > > P
TE MPRAGE/SPGR (ms) 2.98 Shortest (3.1) 2.91 Min Full 2.98 3.1
TR PD/T2 (ms) 3,000 3,000 3,000 3,000 3,000 3,000
TE 1 PD/T2 (ms) 11 Shortest (10) 11 Min Full 11 Shortest (10)
TE 2 PD/T2 (ms) 99 96 99 97.2 101 96
TR EPI (ms) 2,000 2,000 2,000 2,000 2,000 2,000
TE EPI (ms) 30 30 30 30 26 30
Flip angle MPRAGE/SPGR (deg) 9 8 9 8 9 8
Flip angle EPI (deg) 90 79 90 90 66 79
Distance factor for EPI (%) 0 0 0 0 25 (1 mm) 0
MRI data format DICOM DICOM DICOM DICOM DICOM DICOM
N-back task software Visual studio E-Prime 2.0.10 E-Prime 2.0.10 E-Prime 2.0.10 Professional E-Prime 2.0.10 E-Prime 2.0.10 Professional
Response pad 4-button right handed 4-button right handed 4-button right handed 4-button right handed 4-button right handed 5-button right handed
Response box connection Parallel port USB USB USB USB USB
TTL pulses box connection Parallel port USB USB USB USB Parallel port
N-back data format TXT TXT TXT TXT TXT TXT
  1. NHS, National Health Service; UCL, University College London; KCL, King’s College London; GE, General Electric; FH/IS, foot-to-head/inferior-to-superior; AP, anterior-to-posterior; RL, right-to-left; FOV, field of view; A > > P, from anterior to posterior; P > > A, from posterior to anterior; R > > L, from right to left; L > > R, – from left to right; TE, echo time; TR, repetition time; TTL, transistor-transistor logic.