Population pharmacokinetic modeling of the Qishe pill in three major traditional Chinese medicine-defined constitutional types of healthy Chinese subjects: study protocol for a randomized controlled trial

Sun, Yue-li; Hou, Ting; Liu, Shu-fen; Zhang, Zhong-liang; Zhang, Ning; Yao, Min; Yang, Long; Shi, Qi; Cui, Xue-jun; Wang, Yong-jun

doi:10.1186/s13063-015-0568-6

Trials

Table 1 General characteristics of the nine traditional Chinese medicine(TCM) constitutional types [3,13,14]

From: Population pharmacokinetic modeling of the Qishe pill in three major traditional Chinese medicine-defined constitutional types of healthy Chinese subjects: study protocol for a randomized controlled trial

	General characteristics	Physical characteristics	Psychological characteristics	Sign of health	Sign of illness
Gentleness	Yin-Yang balanced	Full of vitality and well-proportioned	Mild character	Good cold and hot tolerance, sleep well, good appetite and no fatigue	Less disease
Type A	Yin-Yang balanced	Full of vitality and well-proportioned	Mild character		Less disease
Qi-deficiency^*	Insufficiency of primordial Qi	Weakened muscle^*	No desire to speak	Short of breath, listless and low voice and easy to sweat and fatigue	Palpitations and influenza
Type B	Insufficiency of primordial Qi	Weakened muscle^*	No desire to speak		Palpitations and influenza
Yang-deficiency	More insufficiency of primordial Qi	Slightly muscle atrophy	More quiet and introverted	Intolerance of cold, loose stool, clear abundant urine and easy to catch a cold	Diarrhea
Type C	More insufficiency of primordial Qi	Slightly muscle atrophy	More quiet and introverted		Diarrhea
Yin-deficiency^*	Yin-fluid deficiency	Slim body	Quick-tempered	Feverish palms and soles, dry mouth and throat, dry eyes, flushing cheek, and dry skin is usual	Fatigue syndrome, muscle fatigue^* and insomnia
Type D	Yin-fluid deficiency	Slim body	Quick-tempered		Fatigue syndrome, muscle fatigue^* and insomnia
Phlegm-wetness	Body fluid stasis and phlegm-wetness aggregation	Obese body with accumulate fat around abdomen	Prudent	Feeling body heaviness, chest distress and excessive phlegm, sticky mouth, and sticky sweating in usual	Stroke and Diabetes
Type E	Body fluid stasis and phlegm-wetness aggregation	Obese body with accumulate fat around abdomen	Prudent		Stroke and Diabetes
Wet-heat	Internal accumulation of damp-heat	Slim body	Tend to be irritable	likely to suffer from acne, thirsty, bad breath, bitter taste in the mouth in usual	Constipation, scabies and jaundice
Type F	Internal accumulation of damp-heat	Slim body	Tend to be irritable		Constipation, scabies and jaundice
Blood-stasis^*	Poor blood circulation	All body types	Tend to be annoying and forgetful	Frequent pain^* and ecchymosis and gloomy complexion	Chronic pain^*
Type G	Poor blood circulation	All body types	Tend to be annoying and forgetful	Frequent pain^* and ecchymosis and gloomy complexion	Chronic pain^*
Qi-depression	Depression and stagnation of Qi	Slim body	Depressive, sensitive and suspicious	Frequently sigh, distention and pain in chest	hypochondria
Type H	Depression and stagnation of Qi	Slim body	Depressive, sensitive and suspicious	Frequently sigh, distention and pain in chest	hypochondria
Special diathesis	Special diathesis	All body types	All types	Hypersensitiveness	Asthma and urticaria
Type I	Special diathesis	All body types	All types	Hypersensitiveness	Asthma and urticaria

*The three TCM constitutional types (Qi-deficiency, Yin-deficiency and Blood-stasis) have been selected in this trial.

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ISSN: 1745-6215

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