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Table 1 Non-adherence to transfusion protocol

From: Transfusion Indication Threshold Reduction (TITRe2) randomized controlled trial in cardiac surgery: statistical analysis plan

 

Transfusion outside of protocol

Transfusion according to protocol withheld

Mild

Not applicable

A transfusion took place, but more than 24 hours after the breach of the relevant transfusion threshold

Moderate

Patient transfused, but patient did breach the relevant threshold for transfusion at some point postoperatively (before or after the transfusion outside of protocol)

Patient was not transfused following a breach, but the patient had previously had at least one post-randomization transfusion

Severe

Patient transfused, and patient did not breach the relevant threshold for transfusion at any point postoperatively

Patient was not transfused following a breach, and patient had no post-randomization transfusions

  1. A patient can breach the relevant threshold for transfusion several times, and so there can be more than one case of non-adherence per patient.