Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial

Table 2 Dose adjustment for study antibiotics

	Meropenem	Piperacillin-tazobactam
Creatinine clearance > 50 mL/min	No change	No change
Creatinine clearance 26 to 50 mL/min	1 g every 12 hours	4.5 g every 8 hours
Creatinine clearance 10 to 25 mL/min	500 mg every 12 hours	4.5 g every 12 hours
Creatinine clearance < 10 mL/min	500 mg every 24 hours	4.5 g every 12 hours
Haemodialysis	500 mg every 24 hours and 500 mg after each dialysis	2.25 g every 8 hours and an additional 0.75 g after each dialysis
Peritoneal dialysis	500 mg every 24 hours	2.25 g every 8 hours
Continuous-renal replacement therapy	1 g every 12 hours	4.5 g every 8 hours

ISSN: 1745-6215