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Table 2 Dose adjustment for study antibiotics

From: Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial

  Meropenem Piperacillin-tazobactam
Creatinine clearance > 50 mL/min No change No change
Creatinine clearance 26 to 50 mL/min 1 g every 12 hours 4.5 g every 8 hours
Creatinine clearance 10 to 25 mL/min 500 mg every 12 hours 4.5 g every 12 hours
Creatinine clearance < 10 mL/min 500 mg every 24 hours 4.5 g every 12 hours
Haemodialysis 500 mg every 24 hours and 500 mg after each dialysis 2.25 g every 8 hours and an additional 0.75 g after each dialysis
Peritoneal dialysis 500 mg every 24 hours 2.25 g every 8 hours
Continuous-renal replacement therapy 1 g every 12 hours 4.5 g every 8 hours