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Table 2 Comparison of pharmacokinetic properties of heparin and low molecular weight heparin (LMWH)

From: Arterial indications for the low molecular weight heparins

 

Heparin

LMWH

Bioavailability at low doses (%)

30

90

Bioavailability at high doses (%)

90

90

Elimination

  

Low doses

Cellular uptake

Renal

 

(saturable)

(non-saturable)

High doses

Renal

Renal

Half-life

Dose dependent

Dose independent

 

(30 min–4 h)

(2–4 h)