|  | Results | ||
---|---|---|---|---|
Study | Follow-up duration | Control | Intervention | P * |
Schuler et al [29]†| 1 year (n = 36) | 33% progression, | 28% progression, | < 0.05 |
 |  | 61% no change, | 33% no change, |  |
 |  | 6% regression | 39% regression |  |
Niebauer et al [30]†| 5 years (n = 25) | 75% progression, | 38% progression, | ns |
 |  | 13% no change, | 38% no change, |  |
 |  | 13% regression | 25% regression |  |
Schuler et al [31]†| 1 year (n = 113) | 48% progression, | 23% progression, | < 0.05 |
 |  | 35% no change, | 45% no change, |  |
 |  | 17% regression | 33% regression |  |
Niebauer et al [33]†| 6 years | 74% progression, | 59% progression, | < 0.0001 |
 |  | 26% no change, | 22% no change, |  |
 |  | 0% regression | 19% regression |  |
1 year (n = 41) | 2.28 (-3.00 to 4.86) (n = 15) | -1.75 (-4.08 to 0.58) (n = 18) | 0.02 | |
 |  | (53% progression, | 18% progression, |  |
 |  | 5% no change, | (0% no change, |  |
 |  | 42% regression) | 82% regression) |  |
 | 5 years (n = 35) | 11.77 (3.40–20.14) (n = 15) | -3.07 (-5.91 to -0.24) (n = 20) | 0.001 |
SCRIP [36]§ | 4 years (n = 246) | -0.045 ± 0.073 | -0.024 ± 0.067 | 0.02 |
 |  | (50% progression, | (50% progression, |  |
 |  | 20% no change, | 18% no change, |  |
 |  | 10% regression, | 20% regression, |  |
 |  | 21% mixed changes) | 12% mixed changes) |  |