Skip to main content

Table 5 Percentage differences between active and placebo groups at different time points

From: Design and intermediate results of the Lower Extremity Arterial Disease Event Reduction (LEADER)* trial of bezafibrate in men with lower extremity arterial disease [ISRCTN41194621]

Parameter 3/6 months (n = 1417) 1 year (n = 1156) 2 years (n = 917) 3 years (n = 723)
Total cholesterol 7.7 (6.7–8.7) 8.4 (7.0–9.7) 7.8 (6.3–9.3) 8.1 (6.3–9.9)
HDL-cholesterol 10.6 (8.9–12.2) 9.4 (7.2–11.6) 7.3 (5.1–9.6) 6.2 (3.3–9.1)
LDL-cholesterol 9.2 (7.5–10.9) 9.4 (7.2–11.6) 8.1 (5.6–10.6) 9.3 (6.1–12.5)
Triglycerides 23.0 (20.1–25.9) 23.3 (19.6–27.1) 25.4 (21.2–29.7) 23.4 (18.3–28.5)
Fibrinogen 12.4 (10.8–13.9) 14.4 (12.4–16.3) 14.2 (11.9–16.5) 13.2 (10.6–15.9)
Creatinine 13.1 (11.8–14.3) 13.2 (11.7–14.7) 11.6 (9.8–13.4) 9.4 (7.1–11.6)
Alkaline phosphatase 30.6 (29.0–32.1) 33.5 (29.5–37.6) 33.4 (30.6–36.3) 32.3 (29.3–35.2)
  1. Percentage differences (95% confidence intervals) between active and placebo groups at 3/6 months (average), 1 year, 2 years and 3 years. For statistical methods, see text. All group differences were significant, at P < 0.0001.