The effect of ramipril on carotid atherosclerosis in the SECURE trial. There was a dose-dependent benefit with reduction in atherosclerosis progression attained with ramipril whcih was more effective at the higher dose of 10 mg/day than in the lower dose of 2.5 mg/day. P = 0.033 overall ramipril effect. *P = 0.028 for ramipril 10 mg/day versus placebo. Mean maximum IMT = average of maximum intimal-medial thickness across 12 predefined carotid arterial segments.