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Table 4 Novel immunosuppressive strategies

From: New immunosuppressive drugs in heart transplantation

Site of action Agent Human studies
Interruption of TCR/MHC   
binding   
   CD4/MHC class II Anti-CD4 mAbs Yes
Interruption of T cell   
co-stimulation   
   CD28/B7 CTLA4-Ig Yes (psoriasis)
   CD40/CD154 Anti-ICAM-1 mAbs Yes (ITP)
Interruption of cell adhesion   
   LFA-1/ICAM-1 Anti-LFA-1 mAbs Yes
  Anti-ICAM-1 mAbs Yes
Interruption of accessory   
molecule interactions   
   CD2/LFA-3 Anti-LFA-3 mAbs No
  Anti-CD2 mAbs Yes
   CD45 Anti-CD45 Yes
  1. ICAM-1, intracellular adhesion molecule-1; ITP, idiopathic thrombocytopenic purpura; LFA, lymphocyte function associated antigen; mAb, monoclonal antibody; MHC, major histocompatibility complex; TCR, T cell receptor.