Table 5 Requirements of a validated surrogate for DWI and PWI
From: Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials
To fully establish diffusion and perfusion MRI as a useful tool and | |
validated surrogate in stroke trials, several conditions need to be | |
satisfied (the first four have been met; see text): | |
1. | DWI and PWI as biologic markers of the disease process in |
| Â | ischemic stroke |
2. | The tests are sensitive and specific for the diagnosis of stroke |
| Â | in patients |
3. | Lesion volumes correlate with clinical function as measured by |
| Â | clinical rating scales, predict outcome, and co-vary over time |
| Â | with clinical severity |
4. | Rational co-variates affecting lesion volumes identified |
5. | Utility in identifying effective treatments in trials proven |