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Table 1 Characteristics of included publications

From: Reporting of noninferiority and equivalence randomized trials for major prostaglandins: A systematic survey of the ophthalmology literature

Author Year Sample Size
(N completed)
Treatment Comparison
Topouzis et al [40] 2007 332 Travoprost 0.004%/timolol 0.5% versus once-daily latanoprost 0.005%/timolol 0.5%
Hommer [43] 2007 430 FC bimatoprost 0.03%/timolol 0.5% versus non-FC bimatoprost 0.03%/timolol 0.5%
Hollo et al [44] 2006 192 Timolol maleate versus brinzolamide both added to travoprost
Brittain et al [20] 2006 46 Combination timolol 0.5% and latanoprost 0.005% versus bimatoprost 0.03%
Day et al [21] 2005 32 bimatoprost 0.03% versus timolol maleate 0.5%/dorzolamide 2% FC
Netland et al [45] 2003 25 Brimonidine purite + bimatoprost versus timolol + latanoprost
Thomas et al [28] 2003 26 Latanoprost versus brimonidine
Whitcup et al [16] 2003 550 Bimatoprost versus timolol
Netland et al [23] 2001 760 Travoprost versus latanoprost versus timolol
Larsson [24] 2001 24 Latanoprost 0.005% versus timolol gel-forming solution 0.5%
Fechtner et al [42] 2004 238 FC dorzolamide 2%/timolol 0.5% (COSOPT™) versus latanoprost 0.005% (XALATAN™)
Cohen et al [17] 2004 284 Bimatoprost versus timolol
Shin et al [31] 2004 242 FC latanoprost/timolol versus FC dorzolamide/timolol
Tomita et al [25] 2004 39 Latanoprost versus timolol
Stewart et al [46] 2004 32 Latanoprost/timolol maleate FC versus concomitant brimonidine and latanoprost therapy
Gandolfi et al [11] 2001 214 Bimatoprost versus latanoprost
Watson et al [26] 1996 268 Latanoprost versus timolol
Konstas et al [57] 2002 35 Once-daily morning versus evening dosing of concomitant latanoprost/timolol
Day et al [47] 2003 31 Timolol 0.5%/Dorzolamide 2% FC versus timolol maleate 0.5% and unoprostone...
Parrish et al [12] 2003 410 Latanoprost versus bimatoprost versus Travoprost
Konstas et al [32] 2004 32 FC latanoprost 0.005%/timolol maleate 0.5% versus FC dorzolamide 2%/timolol maleate 0.5%
Sharpe et al [48] 2005 29 Brimonidine 0.2% versus unoprostone 0.15% both added to timolol maleate 0.5%
Higginbotham et al [18] 2002 1009 Bimatoprost versus timolol
Pfeiffer [33] 2002 396 FC latanoprost and timolol versus its individual components
Higginbotham et al [34] 2002 345 FC latanoprost and timolol versus monotherapy with either components
Konstas et al [49] 2008 53 Latanoprost and dorzolamide/timolol FC after 2 and 6 months of treatment
Konstas et al [37] 2007 40 Latanoprost versus travoprost
Franks et al [39] 2006 106 Travoprost 0.004% versus FC latanoprost 0.005%/timolol 0.5%
Diestelhorst et al [35] 2006 502 FC latanoprost and timolol in the evening versus concomitant use of the individual components
Hughes et al [41] 2005 293 FC travoprost 0.004%/timolol 0.5% ophthalmic solution versus concomitant use of the individual components
Schuman et al [50] 2005 387 FC travoprost 0.004%/timolol 0.5% versus concomitant travoprost 0.004% + timolol 0.5 versus timolol BID control
Konstas et al [29] 2005 31 Brimonidine purite versus dorzolamide each added to latanoprost
Diestelhorst et al [36] 2004 190 FC latanoprost/timolol versus concomitant latanoprost and timolol
Coleman et al [22] 2003 168 Bimatoprost (LUMIGAN) versus combined timolol and dorzolamide (COSOPT)
Zimmerman et al [13] 2003 2775 Various POAG monotherapy versus latanoprost
Stewart et al [51] 2003 29 FC timolol maleate/latanoprost versus timolol maleate + brimonidine
Noecker et al [14] 2003 249 Bimatoprost versus latanoprost
Honrubia et al [52] 2002 217 Latanoprost 0.005% versus FC dorzolamide 2% & timolol 0.5%
Simmons et al [30] 2002 107 Brimonidine versus latanoprost in patients uncontrolled on β – blockers
Goldberg et al [38] 2001 507 Topical travoprost versus timolol BID
DuBiner et al [15] 2001 59 Bimatoprost versus latanoprost
Brandt et al [19] 2001 556 QD, BID bimatoprost versus timolol BID
Susanna et al [53] 2001 98 Latanoprost versus unoprostone
Diestelhorst et al [54] 2000 179 Latanoprost versus pilocarpine T.I.D
Stewart et al [55] 1999 30 Timolol solution versus timolol gel each added to latanoprost
Konstas et al [27] 1999 34 Latanoprost versus timolol maleate
Petounis et al [56] 2001 148 Latanoprost versus dorzolamide each added to timolol