Table 1 Characteristics of included publications

Topouzis et al [40]

Travoprost 0.004%/timolol 0.5% versus once-daily latanoprost 0.005%/timolol 0.5%

Hommer [43]

FC bimatoprost 0.03%/timolol 0.5% versus non-FC bimatoprost 0.03%/timolol 0.5%

Hollo et al [44]

Timolol maleate versus brinzolamide both added to travoprost

Brittain et al [20]

Combination timolol 0.5% and latanoprost 0.005% versus bimatoprost 0.03%

Day et al [21]

bimatoprost 0.03% versus timolol maleate 0.5%/dorzolamide 2% FC

Netland et al [45]

Brimonidine purite + bimatoprost versus timolol + latanoprost

Thomas et al [28]

Latanoprost versus brimonidine

Whitcup et al [16]

Bimatoprost versus timolol

Netland et al [23]

Travoprost versus latanoprost versus timolol

Larsson [24]

Latanoprost 0.005% versus timolol gel-forming solution 0.5%

Fechtner et al [42]

FC dorzolamide 2%/timolol 0.5% (COSOPT™) versus latanoprost 0.005% (XALATAN™)

Cohen et al [17]

Bimatoprost versus timolol

Shin et al [31]

FC latanoprost/timolol versus FC dorzolamide/timolol

Tomita et al [25]

Latanoprost versus timolol

Stewart et al [46]

Latanoprost/timolol maleate FC versus concomitant brimonidine and latanoprost therapy

Gandolfi et al [11]

Bimatoprost versus latanoprost

Watson et al [26]

Latanoprost versus timolol

Konstas et al [57]

Once-daily morning versus evening dosing of concomitant latanoprost/timolol

Day et al [47]

Timolol 0.5%/Dorzolamide 2% FC versus timolol maleate 0.5% and unoprostone...

Parrish et al [12]

Latanoprost versus bimatoprost versus Travoprost

Konstas et al [32]

FC latanoprost 0.005%/timolol maleate 0.5% versus FC dorzolamide 2%/timolol maleate 0.5%

Sharpe et al [48]

Brimonidine 0.2% versus unoprostone 0.15% both added to timolol maleate 0.5%

Higginbotham et al [18]

Bimatoprost versus timolol

Pfeiffer [33]

FC latanoprost and timolol versus its individual components

Higginbotham et al [34]

FC latanoprost and timolol versus monotherapy with either components

Konstas et al [49]

Latanoprost and dorzolamide/timolol FC after 2 and 6 months of treatment

Konstas et al [37]

Latanoprost versus travoprost

Franks et al [39]

Travoprost 0.004% versus FC latanoprost 0.005%/timolol 0.5%

Diestelhorst et al [35]

FC latanoprost and timolol in the evening versus concomitant use of the individual components

Hughes et al [41]

FC travoprost 0.004%/timolol 0.5% ophthalmic solution versus concomitant use of the individual components

Schuman et al [50]

FC travoprost 0.004%/timolol 0.5% versus concomitant travoprost 0.004% + timolol 0.5 versus timolol BID control

Konstas et al [29]

Brimonidine purite versus dorzolamide each added to latanoprost

Diestelhorst et al [36]

FC latanoprost/timolol versus concomitant latanoprost and timolol

Coleman et al [22]

Bimatoprost (LUMIGAN) versus combined timolol and dorzolamide (COSOPT)

Zimmerman et al [13]

Various POAG monotherapy versus latanoprost

Stewart et al [51]

FC timolol maleate/latanoprost versus timolol maleate + brimonidine

Noecker et al [14]

Bimatoprost versus latanoprost

Honrubia et al [52]

Latanoprost 0.005% versus FC dorzolamide 2% & timolol 0.5%

Simmons et al [30]

Brimonidine versus latanoprost in patients uncontrolled on β – blockers

Goldberg et al [38]

Topical travoprost versus timolol BID

DuBiner et al [15]

Bimatoprost versus latanoprost

Brandt et al [19]

QD, BID bimatoprost versus timolol BID

Susanna et al [53]

Latanoprost versus unoprostone

Diestelhorst et al [54]

Latanoprost versus pilocarpine T.I.D

Stewart et al [55]

Timolol solution versus timolol gel each added to latanoprost

Konstas et al [27]

Latanoprost versus timolol maleate

Petounis et al [56]

Latanoprost versus dorzolamide each added to timolol