From: Reporting of clinical trials: a review of research funders' guidelines
Action | Number of organisations (percentage) | Number of charities (percentage) | Total (percentage) |
---|---|---|---|
Contacted | 25 | 115 | 140 |
Eligibility | Â | Â | Â |
Eligible | 17 (68%) | 56 (49%) | 73 (52%) |
Not eligible | 4 (16%) | 48 (42%) | 52 (37%) |
No reply | 0 (0%) | 11 (9%) | 11 (8%) |
Issue guidelines but do not fund RCTs | 4 (16%) | 0 (0%) | 4 (3%) |
Guidelines (n = 73) | Â | Â | Â |
Guidelines/terms and conditions received | 14 (82%) | 52 (93%) | 66 (90%) |
Limited contact | 2 (12%) | 1 (2%) | 3 (4%) |
No guidelines | 1 (6%) | 1 (2%) | 2 (3%) |
Could not send due to confidentiality | 0 (0%) | 2 (3%) | 2 (3%) |
Research funder not checked table of information | 3 (18%) | 8 (14%) | 11 (15%) |
Not referred to other guidelines | 3 (18%) | 14 (25%) | 17 (23%) |
Referred to other guidelines: 1 | 14 (82%) | 42 (75%) | 56 (77%) |
Association of Medical Research Charities | 0 (0%) | 18 (43%) | 18 (32%) |
Department of Health Research Governance Framework (England) | 3 (21%) | 15 (36%) | 18 (32%) |
Medical Research Council | 5 (36%) | 13 (31%) | 18 (32%) |
International Conference on Harmonisation (ICH) | 10 (71%) | 4 (10%) | 14 (25%) |
Medicines for Human use | 6 (43%) | 8 (19%) | 14 (25%) |
Institution | 0 (0%) | 11 (26%) | 11 (20%) |
Declaration of Helsinki | 7 (50%) | 2 (5%) | 9 (16%) |
CONSORT | 6 (43%) | 0 (0%) | 6 (11%) |
Charity specific | 0 (0%) | 4 (10%) | 4 (7%) |
National regulations and guidelines | 1 (7%) | 3 (7%) | 4 (7%) |
Legal | 0 (0%) | 4 (10%) | 4 (7%) |
Wellcome Trust | 0 (0%) | 3 (7%) | 3 (5%) |
Reference in guidelines/through contact (n = 73) to: | Â | Â | Â |
Trial registration explicitly | 12 (71%) | 7 (13%) | 19 (26%) |
Trial registration implicitly | 0 (0%) | 29 (52%) | 29 (40%) |
Protocol adherence/amendment explicitly | 12 (71%) | 20 (36%) | 32 (44%) |
Protocol adherence/amendment implicitly | 2 (12%) | 24 (43%) | 26 (36%) |
Trial publication explicitly | 14 (82%) | 35 (63%) | 49 (67%) |
Trial publication implicitly | 1 (6%) | 13 (23%) | 14 (19%) |
Monitoring against guidelines explicitly | 11 (65%) | 36 (64%) | 47 (64%) |
Monitoring against guidelines implicitly | 1 (6%) | 11 (20%) | 12 (16%) |
Publication of negative studies explicitly | 6 (35%) | 5 (9%) | 11 (15%) |
Publication of negative studies implicitly | 3 (18%) | 24 (43%) | 27 (37%) |
Publication of negative outcomes explicitly | 6 (35%) | 5 (9%) | 11 (15%) |
Publication of negative outcomes implicitly | 3 (18%) | 24 (43%) | 27 (37%) |