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Table 6 Minimisation Criteria

From: Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Minimisation criteria Categories
Smoker at time of TED diagnosis Yes/No
Previous Steroid use* Yes/No
Gender Male/Female
Disease severity TES < 22/TES ≥ 22
Study Centre MEH/BEH/WEH/UCLH/MREH
Disease duration < 6 months/≥ 6 months
Age < 60 years old/≥ 60 years old
Disease activity CAS 2–3/4–5/6–7
Thyroid status on enrolment Hypothyroid/Euthyroid/Hyperthyroid
  1. * Defined as ≥ 20 mg of prednisolone for ≥ 1 month in the previous 6 months
  2. TES: Total Eye Score; MEH: Moorfields Eye Hospital; BEH: Bristol Eye Hospital; WEH: Western Eye Hospital; UCLH: University College London Hospital; MREH: Manchester Royal Eye Hospital; CAS: Clinical Activity Score.