Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Table 6 Minimisation Criteria

Minimisation criteria	Categories
Smoker at time of TED diagnosis	Yes/No
Previous Steroid use*	Yes/No
Gender	Male/Female
Disease severity	TES < 22/TES ≥ 22
Study Centre	MEH/BEH/WEH/UCLH/MREH
Disease duration	< 6 months/≥ 6 months
Age	< 60 years old/≥ 60 years old
Disease activity	CAS 2–3/4–5/6–7
Thyroid status on enrolment	Hypothyroid/Euthyroid/Hyperthyroid

* Defined as ≥ 20 mg of prednisolone for ≥ 1 month in the previous 6 months
TES: Total Eye Score; MEH: Moorfields Eye Hospital; BEH: Bristol Eye Hospital; WEH: Western Eye Hospital; UCLH: University College London Hospital; MREH: Manchester Royal Eye Hospital; CAS: Clinical Activity Score.