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Table 1 Clinical Activity Score

From: Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

PAIN Pain on eye movement in the last 4 weeks
  Pain or oppressive feeling on or behind globe in the last 4 weeks
REDNESS Conjunctival redness
  Eyelid redness
SWELLING Chemosis
  Swollen caruncle
  Eyelid oedema
  * Increasing proptosis of ≥ 2 mm during a period of 1–3 months
IMPAIRED FUNCTION * Decrease in eye movement in any direction of ≥ 8° during a period of 1–3 months
  * Decrease in visual acuity of ≥ 1 line on the Snellen chart (using a pinhole) during a period of 1–3 months
  1. 1 point for each feature present.
  2. *Criteria only counted at follow-up visits.
  3. Maximum Clinical Activity Score is 7 at enrolment visit and 10 at follow-up visits.