Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Table 1 Clinical Activity Score

PAIN	Pain on eye movement in the last 4 weeks
	Pain or oppressive feeling on or behind globe in the last 4 weeks
REDNESS	Conjunctival redness
	Eyelid redness
SWELLING	Chemosis
	Swollen caruncle
	Eyelid oedema
	* Increasing proptosis of ≥ 2 mm during a period of 1–3 months
IMPAIRED FUNCTION	* Decrease in eye movement in any direction of ≥ 8° during a period of 1–3 months
	* Decrease in visual acuity of ≥ 1 line on the Snellen chart (using a pinhole) during a period of 1–3 months

1 point for each feature present.
*Criteria only counted at follow-up visits.
Maximum Clinical Activity Score is 7 at enrolment visit and 10 at follow-up visits.