Skip to main content
Figure 2 | Trials

Figure 2

From: Pearls and perils of an implantable defibrillator trial using a common control: implications for the design of future studies

Figure 2

Depiction of a trial using a common control design testing the same clinical question as one with 2 separate controls (shown in figure 1). The corresponding study-wide alpha (α) and beta (β) calculations are depicted below the design. The designated relative samples sizes are those for maximum efficiency. In the common control design shown, the active treatments of amiodarone and a defibrillator are compared against a common control, which is administered an oral placebo. The most efficient allocation of patients to these treatments and the common control is in the ratio of 1:1:√2.

Back to article page

Trials

ISSN: 1745-6215