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Figure 1 | Trials

Figure 1

From: Pearls and perils of an implantable defibrillator trial using a common control: implications for the design of future studies

Figure 1

Depiction of a trial designed with 2 separate controls. The corresponding study-wide alpha (α) and beta (β) calculations are depicted below the design. The designated relative samples sizes are those for maximum efficiency. In the separate control trial design shown, two trials operate side-by-side, one comparing amiodarone to its own placebo control and the other comparing a defibrillator to its own (sham) control. The most efficient allocation of patients in this instance is 1:1.

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Trials

ISSN: 1745-6215