Table 1 Comparison of demographic, clinical and echocardiographic variables of HC patients with and without severe heart failure symptoms (NYHA class I-II vs. NYHA class II-IV)
Variable | Severe symptom + (n = 17) | Severe symptom – (n = 69) | p |
|---|---|---|---|
Demographics | Â | Â | Â |
Female gender | 10 (59%) | 17 (25%) | 0.003 |
Age (years) | 54 ± 17 | 43 ± 16 | 0.03 |
Blood pressure, mmHg | 116/67 | 114/67 | NS |
Medical therapy | Â | Â | Â |
Beta-blockers | 14 (86%) | 57 (84%) | NS |
Calcium channel blockers | 2 (13%) | 10 (15%) | NS |
Echocardiographic findings | Â | Â | Â |
Left atrium, mm | 46 ± 6 | 44 ± 8 | NS |
LV end-diastolic diameter, mm | 38 ± 8 | 42 ± 5 | NS |
LV end-systolic diameter, mm | 21 ± 5 | 24 ± 5 | NS |
Maximal wall thickness, mm | 25 ± 6 | 24 ± 5 | NS |
Posterior wall diastolic thickness, mm | 16 ± 9 | 13 ± 5 | NS |
Mitral E velocity, m/s | 0.72 ± 0.2 | 0.77 ± 0.2 | NS |
Mitral A velocity, m/s | 0.88 ± 0.3 | 0.80 ± 0.3 | NS |
E deceleration time, ms | 267 ± 61 | 212 ± 76 | 0.004 |
IVRT, ms | 113 ± 29 | 108 ± 30 | NS |
LV ejection fraction, (%) | 75 ± 10 | 76 ± 8 | NS |
LV outflow obstruction, n (%) | 16 (82%) | 29 (42%) | 0.0001 |
Tissue Doppler velocities | Â | Â | Â |
E/Ea (septal) | 33 ± 24 | 24 ± 17 | 0.03 |
E/Ea (lateral mitral) | 33 ± 32 | 18 ± 16 | 0.004 |
Lateral mitral Ea, cm/s | 3.2 ± 1.4 | 4.5 ± 2.5 | 0.007 |
Lateral mitral Aa, cm/s | 4.0 ± 2.3 | 5.4 ± 2.9 | 0.05 |
Lateral mitral Sa, cm/s | 3.1 ± 1.4 | 4.7 ± 1.9 | 0.001 |
Septal mitral Ea, cm/s | 2.8 ± 1.5 | 3.5 ± 1.9 | NS |
Septal mitral Aa, cm/s | 4.7 ± 1.9 | 5.5 ± 1.9 | NS |
Septal mitral Sa, cm/s | 3.7 ± 1.3 | 4.5 ± 1.4 | 0.03 |
Lateral tricuspid Ea, cm/s | 6.7 ± 2.5 | 7.7 ± 3.0 | NS |
Lateral tricuspid Aa, cm/s | 8.8 ± 3.5 | 10.0 ± 3.8 | NS |
Lateral tricuspid Sa, cm/s | 9.7 ± 1.9 | 10.2 ± 3.1 | NS |