Table 6 Unmet needs for outcomes of trials in ulcerative colitis

For each index of disease activity:

Quantify the inter-observer variation for disease activity

Quantify the inter-observer variation for the degree of change between paired videos

Evaluate the relation between endoscopic score and clinical symptoms

Evaluate the relation between endoscopic activity and histological activity

Develop a consensus on a standard set of outcomes of disease activity to collect and report

Develop a consensus on a standard set of outcomes of clinical relevance to patients to collect and report (e.g. time to steroid-free remission, cumulative time off work or normal activities, hospital admission, colectomy)