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Table 2 The four trials

From: Financial considerations in the conduct of multi-centre randomised controlled trials: evidence from a qualitative study

TRIAL SPECIALTY POPULATION MANAGEMENT RECRUITMENT SETTING INTERVENTIONS DESIGN FUNDERS
HPS
(The H eart P rotection S tudy)
Cardiovascular health promotion Patients at increased risk of coronary heart disease Clinical Trials Unit Hospital - Statins (Simvastatin)
-Antioxidant vitamins
- Placebo
4 arm randomised trial (2 × 2 factorial) MRC
BHF
Industry
FOCUS
(Trial of Chemotherapy for Bowel Cancer (F luorouracil, O xaliplatin and Irinotecan (C PT11), U se and S equencing)
Oncology Patients with advanced metastatic colorectal cancer Clinical Trials Unit Hospital Chemotherapeutic agents
- Modified de gramont with fluorouracil
- Irinotecan
- Oxaliplatin
5 arm randomised trial with cross-over MRC
Industry
NHS Trusts
ELEVATE
(A pragmatic single-blind RCT and health economic evaluation of leukotriene receptor antagonists in primary care at steps two and three of the National Asthma Guidelines)
Asthma management Primary care patients with asthma requiring regular preventative treatment or an increase in therapy University Department General Practice - Leukotriene receptor antagonists
- Inhaled corticosteroids
- long-acting beta agonists
3 arm randomised trial (with option to switch treatments post-randomisation and parallel non-randomised 'naturalistic' cohort for patients refusing randomisation) HTA
Industry
PCTs
TOuCAN
(T rial of O utcome for C hild &A dolescent Anorexia N ervosa)
Adolescent psychiatry Adolescents (aged 12–18) with anorexia nervosa Hospital/university Hospital and out-patient service - intensive inpatient treatment
- general local outpatient service
- specialist outpatient service
2 severity strata (steps) with 2 arms at each step HTA