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Table 4 Net benefit for treating high-risk and all patients, varying the event rate in the absence of intervention.

From: Selecting patients for randomized trials: a systematic approach based on risk group

Event rate in the absence of intervention

Net benefit (high-risk)

Net benefit (treat all)

Net benefit compared to treat all

50%

0.09713

0.12000

-0.02288

10%

0.01803

0.02000

-0.00198

7.5%

0.01308

0.01375

-0.00067

5%

0.00814

0.00750

0.00064

2.5%

0.00319

0.00125

0.00194

1%

0.00023

-0.00250

0.00273

  1. Results are for a scenario where relative risk = 0.75; sensitivity = 80%; specificity = 65% and NNTt = 200