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Table 1 Inclusion criteria – HETRASE study

From: A randomized clinical trial of unfractioned heparin for treatment of sepsis (the HETRASE study): design and rationale [NCT00100308]

Modified CDC definitions for infection

General variables

Inflammatory variables

1) Pneumonia

1) Temperature (oral or axillary) > 38°C or < 36°C

1) WBC > 12,000 μL-1 or < 4,000 μL-1 or with > 10% immature forms

2) Bloodstream infection

2) Heart rate > 90 beats/min

2) Plasma C-reactive protein > 5 mg/dL.

3) Clinical sepsis

3) Respiratory rate > 20 breaths/min

 

4) Symptomatic urinary tract infection and other infections of urinary tract

4) Altered mental status determined by Glasgow Coma Scale < 15

 

5) Intra-abdominal infections

5) Systolic blood pressure < 90 mm Hg or a decrease > 40 mm Hg

 

6) Skin infections

  

7) Soft tissue infections

  

8) Superficial and deep surgical site infections

  

9) Joint or bursa infections