Table 1 Overall inclusion and exclusion criteria of the MedSeq project patient participants, plus additional criteria specific to the primary care or subspecialty cardiology trials

Inclusion criteria

Patients receiving care from MedSeq Project physician participants

Age 40-65 years

Age 18-90 years

Generally healthy, in the judgment of the patient’s participating physician

Diagnosis of hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM)

No indication for a genetic test

Prior or concurrent targeted genetic testing for HCM or DCM

Exclusion criteria

Clinically significant anxiety (Hospital Anxiety and Depression Scale [HADS] anxiety subscale >14) or depression (HADS depression subscale >16) at baseline assessment

Presence of cardiovascular disease or diabetes

Reported current pregnancy or intention for future conception in the next year of participant or spouse/partner