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Table 1 Overall inclusion and exclusion criteria of the MedSeq project patient participants, plus additional criteria specific to the primary care or subspecialty cardiology trials

From: The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine

  Both trials Primary care trial Cardiology trial
Inclusion criteria Patients receiving care from MedSeq Project physician participants Age 40-65 years Age 18-90 years
Generally healthy, in the judgment of the patient’s participating physician Diagnosis of hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM)
No indication for a genetic test Prior or concurrent targeted genetic testing for HCM or DCM
Exclusion criteria Clinically significant anxiety (Hospital Anxiety and Depression Scale [HADS] anxiety subscale >14) or depression (HADS depression subscale >16) at baseline assessment   
Presence of cardiovascular disease or diabetes
  Reported current pregnancy or intention for future conception in the next year of participant or spouse/partner