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Table 2 Number of completed cycles, global means (SD) and range of stimulant and placebo scores, and overall posterior population estimates of the mean difference between stimulant and placebo scores together with the posterior probabilities that the stimulant scores are better than the placebo scores for each study instrument

From: Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury – a pilot study

 

Completed cycle pairs

Stimulant

Placebo

Posterior mean difference1(PMD)

 

n

(%)

Mean

(SD)

(Range)

Mean

(SD)

(Range)

Mean

(SD)

P(PMD?>?0)

Conners 3 Rating Scale Global Index2,3

Parent

18

(90)

10.9

(4.9)

(2 to 18)

13.3

(5.4)

(4 to 21)

2.3

(6.2)

0.92

Teacher

10

(50)

6.5

(4.4)

(0 to 11)

11.0

(5.2)

(2 to 21)

5.9

(4.5)

0.93

Behaviour Rating Inventory of Executive Function2

Parent

18

(90)

147.8

(29.8)

(88 to 204)

152.3

(27.4)

(106 to 195)

10.8

(17.5)

0.76

Teacher

10

(50)

127.4

(24.1)

(87 to 148)

143.2

(20.2)

(100 to 181)

20.7

(23.2)

0.86

Eyberg Child Behaviour Inventory2

Parent: number of problems

17

(85)

8.5

(7.6)

(0 to 27)

10.3

(8.7)

(0 to 25)

2.8

(4.8)

0.75

Parent: intensity of problems

18

(90)

104.8

(26.5)

(62 to 172)

109.1

(31.6)

(47 to 164)

2.9

(13.7)

0.49

Teacher: intensity of problems

10

(50)

74.6

(20.8)

(45 to 103)

93.0

(34.7)

(57 to 176)

24.8

(32.7)

0.83

  1. 1Placebo minus stimulant scores; 2Lower scores indicate less disturbance of behaviour; 3Raw scores.