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Table 2 Number of completed cycles, global means (SD) and range of stimulant and placebo scores, and overall posterior population estimates of the mean difference between stimulant and placebo scores together with the posterior probabilities that the stimulant scores are better than the placebo scores for each study instrument

From: Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury – a pilot study

  Completed cycle pairs Stimulant Placebo Posterior mean difference1(PMD)
  n (%) Mean (SD) (Range) Mean (SD) (Range) Mean (SD) P(PMD?>?0)
Conners 3 Rating Scale Global Index2,3
Parent 18 (90) 10.9 (4.9) (2 to 18) 13.3 (5.4) (4 to 21) 2.3 (6.2) 0.92
Teacher 10 (50) 6.5 (4.4) (0 to 11) 11.0 (5.2) (2 to 21) 5.9 (4.5) 0.93
Behaviour Rating Inventory of Executive Function2
Parent 18 (90) 147.8 (29.8) (88 to 204) 152.3 (27.4) (106 to 195) 10.8 (17.5) 0.76
Teacher 10 (50) 127.4 (24.1) (87 to 148) 143.2 (20.2) (100 to 181) 20.7 (23.2) 0.86
Eyberg Child Behaviour Inventory2
Parent: number of problems 17 (85) 8.5 (7.6) (0 to 27) 10.3 (8.7) (0 to 25) 2.8 (4.8) 0.75
Parent: intensity of problems 18 (90) 104.8 (26.5) (62 to 172) 109.1 (31.6) (47 to 164) 2.9 (13.7) 0.49
Teacher: intensity of problems 10 (50) 74.6 (20.8) (45 to 103) 93.0 (34.7) (57 to 176) 24.8 (32.7) 0.83
  1. 1Placebo minus stimulant scores; 2Lower scores indicate less disturbance of behaviour; 3Raw scores.