Figure 1From: Weekly low-dose methotrexate for reduction of Global Initiative for Asthma Step 5 treatment in severe refractory asthma: study protocol for a randomized controlled trial A schematic diagram of the study design. MTX: Methotrexate. PROs: Patient Reported Outcomes. US: Ultrasound. MTXPG: Methotrexate Polyglutamate. AEs: Adverse Events.Back to article page