Skip to main content

Table 1 Co-enrollment fractions and resultant sample size with 2% antagonistic interaction

From: Ethical and scientific considerations for patient enrollment into concurrent clinical trials

Co-enrollment fraction

Event rate for arm S1

Event rate for arm S2

Difference

Number of patients per arm for 90% power

0%

7.22

8.38

-1.16

11,219

30%

7.24

8.36

-1.11

12,209

50%

7.26

8.34

-1.08

12,943

70%

7.28

8.32

-1.05

13,746

100%

7.30

8.30

-1.00

15,097