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Table 1 Methodology projects

From: Measuring the impact of methodological research: a framework and methods to identify evidence of impact

Project title

Methodology area

Interviewee number*

Flexible parametric models

Statistical

13

Missing data for prognostics

Statistical

13

Multi-variable modelling, prognostic modelling

Statistical

13

Modelling the association between patient characteristics and change over time in a disease measure

Statistical

3

Combining multiple imputation and inverse probability weighting

Statistical

3

New measure of the predictive ability for a survival model

Statistical

7

Bias two-arm multi-stage trials

Statistical

7

Analysis of resources for trials

Statistical

8

Restricted mean survival time

Statistical

4

Multi-arm multi-stage trial design

Statistical

5, 10

Biomarkers

Statistical

4

Comparing dynamic treatment regimens or monitoring strategies

Statistical

11, 12

Estimating the effect of time-varying treatment or exposure on outcome

Statistical

11, 12

Developing guidance for researchers on patient and public involvement in clinical research

Trial conduct

2

Consumer involvement in MRC CTU studies

Trial conduct

2

DAMOCLES (DAta MOnitoring Committees: Lessons, Ethics, Statistics)

Trial conduct

5

Retention strategies for randomized trials

Trial conduct

14

Central monitoring techniques to replace on-site monitoring

Trial conduct

6

Risk-based monitoring of trials

Trial conduct

9

Analysis of subgroup interactions in individual patient data meta-analysis

Meta-analysis

1

Total

20

14

  1. *Interviewees 2, 3, 4, 5, 7, 11, 12 and 13 discussed more than one project. CTU, clinical trials unit; MRC, UK Medical Research Council.