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Table 1 Outcome and disability grading: “two simple questions” and rankin score

From: CryptoDex: A randomised, double-blind, placebo-controlled phase III trial of adjunctive dexamethasone in HIV-infected adults with cryptococcal meningitis: study protocol for a randomised control trial

The two simple questions

Does the patient require help from anybody for everyday activities? (For example eating, drinking, washing, brushing teeth, going to the toilet.)

Yes/no

Yes = Poor outcome

Has the illness left you with any other problems?

Yes/no

Yes = Intermediate outcome

No = Good outcome

The modified rankin scale

Grade

Description

0

No symptoms

1

Minor symptoms not interfering with lifestyle

2

Symptoms that lead to some restriction in lifestyle, but do not interfere with the patients’ ability to look after themselves

3

Symptoms that restrict lifestyle and prevent totally independent living

4

Symptoms that clearly prevent independent living, although the patient does not need constant care and attention

5

Totally dependent, requiring constant help day and night

  1. Grade 0: Good outcome, Grade 1 or 2: Intermediate outcome, Grade 3-5: poor outcome.