The Global Consortium for Drug-resistant Tuberculosis Diagnostics (GCDD): design of a multi-site, head-to-head study of three rapid tests to detect extensively drug-resistant tuberculosis

Table 1 Data collection schedule

Tests, measures, and samples	Clinic or laboratory	Baseline	Day 2	30 days	52 weeks
Sputum sample	Clinic	×	×		×
Blood sample (some study sites)	Clinic	×
Screening interview	Clinic	×
Enrollment interview	Clinic	×
Enrollment chart review	Clinic	×
Day-2 specimen collection	Clinic		×
30-day chart review	Clinic			×
52-week interview	Clinic				×
52-week chart review	Clinic				×
Sample collection	Laboratory	×			×
Sample processing	Laboratory	×			×
Smear microscopy	Laboratory	×			×
Mycobacterial growth indicator tube culture	Laboratory	×			×
Presumptive identification	Laboratory	×			×
Confirmatory identification	Laboratory	×			×
Löwenstein-Jensen culture	Laboratory	×			×
Mycobacterial growth indicator tube drug susceptibility test	Laboratory	×			×
Hain GenoType®MTBDRplus	Laboratory	×
Hain GenoType®MTBDRsl	Laboratory	×
Microscopic observation drug susceptibility assay	Laboratory	×
Pyrosequencing	Laboratory	×
Freezing and storage	Laboratory	×			×

ISSN: 1745-6215