Table 1 The inclusion and the exclusion criteria for the Pilot-CRAfT study
Inclusion criteria: | |
1) | Permanent or long-standing persistent AF (definitions according to the latest ESC guidelines on AF) |
2) | At least three months after the procedure of a CRT device implantation |
3) | A CRT device with the presence of a right atrial electrode |
4) | Age: ≥18 years old |
5) | Effectively biventricular paced captured beats percentage <95% |
6) | Effective therapy with oral anticoagulants for at least three weeks |
7) | Written informed consent |
Exclusion criteria: | |
1) | Reversible causes of AF |
2) | Significant valve disease |
3) | Advanced AV block (including: AVJA) |
4) | Contraindications to amiodarone (hyperthyroidism, non-compensated hypothyroidism, drug intolerance, QT >460 ms for men, QT >450 ms for women) |
5) | Long-QT syndrome |
6) | Cardiac transplantation in six months |
7) | Life expectancy less than one year |
8) | LA diameter larger than 6 cm |
9) | Heart failure decompensation within 48 hours before the qualification |
10) | Chronic dialysis |
11) | History of alcohol abuse |
12) | Pregnancy or lack of effective contraceptive therapy (in case of females in the reproductive age) |
13) | Participation in other clinical trial |