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Table 3 Respondents’ concerns about sharing clinical trial data through a data repository, stratified by trialist and trial characteristics

From: Predictors of clinical trial data sharing: exploratory analysis of a cross-sectional survey

  Concerns about sharing clinical trial data through a data repository
  Respondents No concern (%) Any concern (%) P value Concerns related to investigator or funder interests (%) P value Concerns related to the protection of research subjects (%) P value Concerns related to appropriate data use (%) P value Other concerns (%)
Overall 317 77 (24) 240 (76)   129 (41)   91 (29)   205 (65)   35 (11)
Trialist academic productivity (number of research articles published in past three years)     0.32   0.09   0.59   0.18  
     1 to 10 articles 71 15 (21) 56 (79)   21 (30)   22 (31)   47 (66)   7 (10)
     11 to 25 articles 117 25 (21) 92 (79) 52 (44) 36 (31) 82 (70) 10 (9)
     >25 articles 129 37 (29) 92 (71) 56 (43) 33 (26) 76 (59) 18 (14)
Trialist geographic location     0.88   0.93   0.65   0.70  
     United States or Canada 167 41 (25) 126 (75)   68 (41)   45 (27)   111 (66)   21 (13)
     Western Europe 113 26 (23) 87 (77) 45 (40) 36 (32) 72 (64) 11 (10)
     Other 37 10 (27) 27 (73) 16 (43) 10 (27) 22 (59) 3 (8)
Trial funding source     0.18   0.01   0.34   0.52  
     Government 120 35 (29) 85 (71)   39 (33)   32 (27)   75 (63)   16 (13)
     Industry or mixed funding 152 30 (20) 122 (80) 75 (49) 42 (28) 103 (68) 13 (9)
     Other 45 12 (27) 33 (73) 15 (33) 17 (38) 27 (60) 6 (13)
Trial size     0.35   0.10   0.40   0.84  
     ≤239 subjects 80 24 (30) 56 (70)   26 (33)   24 (30)   52 (65)   9 (11)
     240 to 2,016 subjects 158 34 (22) 124 (78) 64 (41) 49 (31) 104 (66) 16 (10)
     ≥2,017 subjects 79 19 (24) 60 (76) 39 (49) 18 (23) 49 (62) 10 (13)
Journal in which the trial was published     0.29*   0.57   0.81*   0.31  
     NEJM 113 26 (23) 87 (77)   48 (42)   30 (27)   79 (70)   13 (12)
     Lancet 70 11 (16) 59 (84) 31 (44) 18 (26) 48 (69) 5 (7)
     JAMA 43 14 (33) 29 (67) 16 (37) 15 (35) 26 (60) 5 (12)
     Annals of Internal Medicine 24 7 (29) 17 (71) 8 (33) 8 (33) 14 (58) 4 (17)
     The BMJ 53 16 (30) 37 (70) 18 (34) 17 (32) 32 (60) 8 (15)
     PLoS Medicine 14 3 (21) 11 (79)   8 (57)   3 (21)   6 (43)   0 (0)
  1. *Fisher exact test. JAMA, Journal of the American Medical Association; NEJM, New England Journal of Medicine.